Before applying the patch, cleanse and dry your skin thoroughly. Make sure the area is free of oils, creams, and serums. Remove the patch from the pouch and peel off the plastic film. Retain the plastic film. Smooth the patch over the wrinkle, pressing gently to adhere. Wear overnight or for a minimum of three hours. For best results, apply before bed and leave on all night. The patch should stay in place comfortably. Remove after six to eight hours. When removing the patch, gently lift one edge of the patch and slowly peel away from skin. Hold the skin taut with one hand while removing to avoid tugging. Rinse any residue off with water.