Best used with whiteheads. The patches are waterproof with very strong adhesive so you won't have to worry about them coming off easily. You can go about your skincare routine as normal or even apply makeup over the top. The paches for pimples are gentle and suitable for sensitive skin. Each Box comes with (Small and medium sized patches) on easy-peel perforated sheets. Effective in 6-7 hours, just stick on and wear while you sleep or just get on with your day.