5-HTP, derived from Griffonia simplicifolia, is used to boost serotonin levels. It should not be taken with antidepressants, as this can lead to serotonin syndrome. Those with Down syndrome, or a family history of it, should exercise caution due to increased risk of serotonin syndrome. It should be avoided by those with eosinophilia myalgia syndrome or scleroderma. The supplement may cause drowsiness, so caution should be exercised when driving or operating machinery. Pregnant and breastfeeding women should avoid 5-HTP. Always consult a healthcare professional before starting any new supplement, especially if you have any underlying health conditions or are taking medications.